Effects of stimulating interleukin -2/anti- interleukin -2 antibody complexes on renal cell carcinoma
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چکیده
منابع مشابه
Effects of stimulating interleukin -2/anti- interleukin -2 antibody complexes on renal cell carcinoma
BACKGROUND Current therapies for advanced renal cell carcinoma (RCC) have low cure rates or significant side effects. It has been reported that complexes composed of interleukin (IL)-2 and stimulating anti-IL-2 antibody (IL-2C) suppress malignant melanoma growth. We investigated whether it could have similar effects on RCC. METHODS A syngeneic RCC model was established by subcutaneously injec...
متن کاملInterleukin 2 induced cytotoxicity on renal cell carcinoma. 2. Synergistic effects of interleukin 2 and interferon gamma.
In the previous paper, it was shown that interleukin 2 (IL-2) enhanced NK cell activity against renal carcinoma cell lines and fresh solid tumor cells of renal cell carcinoma (RCC) which are not susceptible to NK cells, and that IL-2 in duced a higher cytotoxicity than interferon ƒÁ (IFN-ƒÁ). The present study was carried out to examine the mechanism of the en hanced cytotoxicity of IL-2 and IF...
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High-dose bolus interleukin 2 (IL-2) was granted Food and Drug Administration approval based on its ability to produce durable complete responses in a small number of patients with metastatic renal cell carcinoma. Results from randomized phase 3 trials suggest that regimens involving lower doses of IL-2, either alone or in combination with IFN, produce fewer tumor regressions of less overall qu...
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4662 Background: Pulmonary metastases of renal cell carcinoma (RCC) are associated with poor prognosis especially when the disease is rapidly progressing. The lung is a common site for metastases and respiratory failure is a common cause of death in patients with RCC. Inhalation therapy with IL-2 is thus an appealing method for palliation. This multi-center study summarizes the national experie...
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ژورنال
عنوان ژورنال: BMC Urology
سال: 2016
ISSN: 1471-2490
DOI: 10.1186/s12894-016-0121-2